实验室研究方向:
研究兴趣包括表观遗传学,基因组学和发育生物学。同时利用分子生物学、发育生物学和计算生物学的方法,采用干湿实验结合的方式,研究早期胚胎发育、干细胞分化以及人类疾病中的表观遗传调控机制。本实验室致力于:(1)动物胚胎早期发育过程中的表观遗传调控;(2)干细胞分化过程中的表观遗传调控;(3)调控序列如启动子、增强子、绝缘子以及三维基因组在发育和细胞命运决定过程中的功能;(4)表观遗传相关人类疾病的调控机理。
●实验室主页:
●代表性工作:
1.Zou et al. (2022) Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation. Science
2.Xiong et al.(2022)Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development. Nat Cell Biol
3.Wu et al. (2021) Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. Science Advances.
4.Lu et al. (2021) Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting. Science Advances.
5.Liu et al. (2020) The landscape of RNA Pol II binding reveals a stepwise transition during ZGA. Nature 587 (139–144).
6.Xiang et al. (2020) Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency. Nature Genetics 52 (95-105).
7.Xia et al. (2019) Resetting histone modifications during human parental-to-zygotic transition. Science 365 (353-360).
8.Wu et al. (2018) Chromatin analysis in human early development reveals epigenetic transition during ZGA. Nature 557 (256–260).
9.Du et al. (2017) Allelic reprogramming of 3D chromatin architecture during early mammalian development. Nature 547 (232-235).
10. Zhang et al. (2016).
Allelic reprogramming of the histone modification H3K4me
11. Wu et al. (2016). The landscape of accessible chromatin in mammalian preimplantation embryos. Nature 534 (652-657).
小鼠实验技术员
岗位职责(具体岗位视个人背景情况而定):
协助实验室成员完成实验,包括显微注射、胚胎收集、基因型鉴定、SCNT以及动物手术等工作。
应聘条件:
1.动物学、生物学、兽医学或医学相关专业毕业;
2.善于沟通、思路清晰、认真负责、为人踏实、乐于服务;思想素质良好,作风正派,具有良好的团队合作精神和独立工作及学习能力,积极上进;
3.具有良好的团队合作精神,良好的独立工作及学习能力,积极上进
岗位待遇:
合同聘用制,享受清华大学非事业编制人员待遇(包含五险一金),具体待遇面议。
申请方式:
应聘者请将个人简历发送至邮箱xiangzheng@mail.tsinghua.edu.cn
,邮件主题请注明“小鼠实验技术员应聘+姓名+高校人才网”。若符合条件,我们将邮件通知后续面试事宜。
信息来源于网络,如有变更请以原发布者为准。
来源链接:
http://www.cls.edu.cn/Careers/Technician6095.shtml