The Department of Pharmacology and Neuroscience, Creighton University School of Medicine, is seeking two research scientists or postdoctoral fellows for an NIH funded project.
美国克莱顿大学医学院药理学和神经科学系正在为美国国立卫生研究院资助的项目寻找两名研究科学家或博士后研究员。
01.关键职责
Airway hyperresponsiveness and airway inflammation are hallmarks of asthma that is clinically managed with β2-agonist bronchodilators and inhaled corticosteroids. Refractory asthma manifests with persistent symptoms despite the use of high-dose oral corticosteroids and long-acting β2-agonists and poses a major healthcare challenge. Understanding the molecular mechanisms of therapeutic resistance and developing strategies to overcome such resistance poses a significant unmet need.
气道反应过高和气道炎症是哮喘的标志，通过β2激动剂支气管扩张剂和吸入皮质类固醇进行临床治疗。尽管使用大剂量口服皮质类固醇和长效β2激动剂，但难治性哮喘仍然表现出持续的症状，并构成了重大的医疗保健挑战。了解治疗耐药性的分子机制并制定克服这种耐药性的策略，是重大的未满足需求。
1.We are seeking talented, highly motivated individuals who are broadly interested in the molecular and cellular basis of refractory asthma. Our research focuses on understanding the molecular mechanisms of therapeutic resistance and developing new strategies to overcome such resistance in refractory asthma.
1，我们正在寻找对难治性哮喘的分子和细胞基础广泛感兴趣的有才华、积极性高的人。研究重点是了解治疗耐药性的分子机制，并制定新的策略来克服难治性哮喘的这种耐药性。2.Ideal candidate will be expected to develop the project independently and will also have the opportunity to interact and participate in other studies of our multidisciplinary group in the lab and throughout the department. Our research team highly values creativity and independence in a collaborative and collegial academic environment.
2，理想的候选人有望独立开发该项目，并有机会在实验室和整个部门互动和参与我们多学科小组的其他研究。我们的研究团队高度重视在协作和合议学术环境中的创造力和独立性。
3.Successful candidates will have a doctorate in areas related to cell and molecular biology, immunology, signal transduction, asthma or cancer, supported by strong publications. Prior experience in airway smooth muscle cells and mouse models of asthma and/or cancer would be advantageous.
3，成功的候选人将获得细胞和分子生物学、免疫学、信号转导、哮喘或癌症相关领域的博士学位，并得到强有力的出版物的支持。之前在气道平滑肌细胞和哮喘和/或癌症的小鼠模型方面的经验将是有利的。
4.Candidates will also be asked to assist in training of laboratory staff and graduate students in research techniques as well as writing grant proposals. This is a full time, grant funded role.
4，候选人还将可以协助培训实验室工作人员和研究生研究技术以及撰写赠款提案，这是一个全职、赠款资助的角色。
02.申请资格
•Applicants should have a Ph.D., M.D., or M.D./Ph.D. degree
•申请人应拥有博士学位、医学博士学位或医学博士学位/博士学位
• Significant research accomplishments and scholarly promise
•重要的研究成就和学术前景
03.如何申请
Applicants can send the following materials to Prof. Yaping Tu
(Yat60399@creighton.edu).
1.Curriculum vitae
2.A brief summary of research to date and preferred research directions for the next few years
3.Names of three referees who can write letters of recommendation (at least one outside the applicant’s home institution)
申请人可以将以下材料发送给Yaping Tu教授（Yat60399@creighton.edu）。
1.简历
2.迄今为止的研究摘要和未来几年的首选研究方向
3.三名可以写推荐信的推荐人的姓名（至少在申请人所在地机构外有一名）
美国克莱顿大学是一所位于美国内布拉斯加州奥马哈的私立研究型大学。它成立于1878年，在2022-2023年版的最佳学院中排名第115位，在美国最具价值学校中排名第90位。
